Positive regulation of alcohol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPAL2, TUT4, and HP1BP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIPAL2 grouped by Positive regulation of alcohol biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NIPAL2 →	-1.268	-0.310	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TUT4 →	+1.115	+0.213	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	HP1BP3 →	+1.437	+0.184	<.001	.007	3	4
LIVER	SNX22 →	+0.589	+0.206	.004	<.001	3	4
SOFT_TISSUE	LDLRAP1 →	-0.752	-0.283	.006	.003	3	4
LIVER	CHRNB1 →	+1.266	+0.267	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIPAL2 by Positive regulation of alcohol biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →