Regulation of alcohol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, BIN2, and NCKAP1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alcohol biosynthetic process activity versus DIPK2B in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DIPK2B →	+0.511	+0.655	<.001	.003	3	8
GBM	BIN2 →	+0.813	+0.333	<.001	.002	3	7
HNSC	NCKAP1L →	+0.809	+0.670	.001	.002	3	7
HNSC	TOP2A →	-1.281	-1.005	<.001	<.001	3	7
HNSC	MICAL1 →	+0.472	+0.558	.001	.004	3	7
HNSC	KIF11 →	-0.758	-0.616	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902930 vs DIPK2B — LSCC

Explore this scatter interactively →