Positive regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIAP29, C12orf56, and ISYNA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein polyubiquitination activity versus PPIAP29 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPIAP29 →	+1.169	+0.516	.001	.002	3	4
OV	C12orf56 →	+0.825	+0.478	.004	.003	3	3
PDAC	ISYNA1 →	-0.436	-0.666	.006	<.001	3	3
CCRCC	FUT1 →	-0.521	-0.408	.001	.003	3	3
PDAC	LPA →	-0.143	-0.967	<.001	<.001	3	3
LUAD	RNU6-94P →	+0.469	+0.431	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902916 vs PPIAP29 — BRCA

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