Regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein polyubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSME2, XAF1, and STAT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein polyubiquitination activity versus PSME2 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSME2 →	+0.294	+0.046	.001	.003	3	8
COAD	XAF1 →	+0.869	+0.032	.003	.006	3	7
CCRCC	STAT1 →	+0.511	+0.032	<.001	.001	3	7
LSCC	PSMB10 →	+0.361	+0.046	<.001	<.001	3	7
COAD	SP110 →	+0.451	+0.026	<.001	.003	3	6
LSCC	IFI35 →	+0.462	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902914 vs PSME2 — LSCC

Explore this scatter interactively →