Regulation of protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf43, MTMR11, and PPM1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf43 grouped by Regulation of protein polyubiquitination-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C1orf43 →	-0.593	-0.300	.007	.004	3	4
STOMACH	MTMR11 →	-2.048	-0.221	.005	.001	2	5
LIVER	PPM1A →	+0.610	+1.535	.007	.002	3	4
LUNG_NSCLC_LUAD	GRK2 →	+0.598	+0.319	.005	.008	3	3
CNS	ARL10 →	+1.391	+0.753	<.001	.003	3	3
LARGE_INTESTINE	FDXR →	-1.138	-0.803	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf43 by Regulation of protein polyubiquitination activity — PANCREAS

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