Regulation of protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOP1, POM121, and TOP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein polyubiquitination activity versus THOP1 in OVARY (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	THOP1 →	+1.038	+0.291	<.001	.007	3	6
LIVER	POM121 →	+1.095	+0.334	<.001	<.001	3	6
LIVER	TOP1 →	+0.944	+0.364	.002	.004	3	6
PANCREAS	METAP2 →	+0.848	+0.480	.001	<.001	3	6
PANCREAS	CCT4 →	+0.777	+0.499	.002	.001	3	6
PANCREAS	HSPE1 →	+0.830	+0.322	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902914 vs THOP1 — OVARY

Explore this scatter interactively →