Regulation of miRNA transcription

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC32, CFAP57, and SAMD12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA transcription activity versus CCDC32 in CNS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCDC32 →	-0.692	-1.319	.001	.001	3	5
OESOPHAGUS	CFAP57 →	+1.045	+1.173	.001	<.001	3	4
OVARY	SAMD12 →	+1.888	+1.141	<.001	.001	2	5
LIVER	NDUFS1 →	-0.563	-1.397	.003	.005	3	4
LARGE_INTESTINE	PIP5K1B →	-2.322	-0.877	<.001	.002	3	4
LUNG_NSCLC_LUSC	SFXN5 →	-1.704	-1.565	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902893 vs CCDC32 — CNS

Explore this scatter interactively →