Negative regulation of response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to oxidative stress pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNL3, MRPL35, and UTP14A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to oxidative stress activity versus GNL3 in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GNL3 →	-0.193	-0.053	<.001	.003	3	5
LSCC	MRPL35 →	-0.464	-0.063	<.001	<.001	3	5
UCEC	UTP14A →	-0.131	-0.043	.006	.005	3	4
OV	FEN1 →	-0.643	-0.056	<.001	.002	3	4
UCEC	ANXA9 →	+0.401	+0.041	.005	.007	3	4
OV	TMPO →	-0.323	-0.048	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902883 vs GNL3 — CCRCC

Explore this scatter interactively →