Negative regulation of response to oxidative stress

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERGIC1, CORO1B, and TNFRSF10D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to oxidative stress activity versus ERGIC1 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERGIC1 →	+1.171	+0.136	<.001	.003	3	5
URINARY_TRACT	CORO1B →	+0.580	+0.181	.003	.003	3	5
OESOPHAGUS	TNFRSF10D →	-2.480	-0.193	.003	.004	3	5
LUNG_NSCLC_LUAD	ANKRD49 →	+0.798	+0.196	<.001	<.001	3	5
BREAST	ANKMY2 →	-0.915	-0.156	.002	<.001	3	4
BLOOD_Leukemia	KATNA1 →	-0.434	-0.092	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902883 vs ERGIC1 — BREAST

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