Positive regulation of non-motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of non-motile cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCAPD2, NCAPG, and LIN54_S635, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of non-motile cilium assembly activity versus NCAPD2 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NCAPD2 →	+0.461	+0.071	<.001	<.001	3	8
BRCA	NCAPG →	+0.640	+0.052	<.001	<.001	3	8
HNSC	LIN54_S635 →	+0.611	+0.105	<.001	<.001	3	7
BRCA	SMC2 →	+0.553	+0.044	.001	.003	3	7
LSCC	SMC4 →	+0.510	+0.071	<.001	<.001	3	7
COAD	CIP2A →	+0.475	+0.051	.008	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902857 vs NCAPD2 — LSCC

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