Positive regulation of non-motile cilium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC17, RAB3A, and DEPTOR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC17 grouped by Positive regulation of non-motile cilium assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAJC17 →	-0.716	-0.532	<.001	.004	3	4
BREAST	RAB3A →	-0.874	-0.839	.009	<.001	3	4
BREAST	DEPTOR →	-1.688	-1.001	.001	<.001	3	4
LIVER	RAPGEF4 →	-1.271	-1.363	.002	.003	3	3
OESOPHAGUS	FARSA →	-0.600	-0.210	.007	<.001	3	3
BLOOD_Myeloma	RPF1 →	-0.926	-1.556	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC17 by Positive regulation of non-motile cilium assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →