Microtubule cytoskeleton organization involved in mitosis

Across TCGA cell cohorts, RNA activity of the Microtubule cytoskeleton organization involved in mitosis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBG1, WRAP53, and TUBA1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule cytoskeleton organization involved in mitosis activity versus TUBG1 in SOFT_TISSUE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TUBG1 →	+0.566	+0.147	.005	.004	3	7
BLOOD_Leukemia	WRAP53 →	+0.946	+0.104	<.001	<.001	3	6
LUNG_SCLC	TUBA1B →	+0.870	+0.256	<.001	<.001	3	6
BONE	HEG1 →	+3.592	+0.183	.001	.008	3	5
BLOOD_Leukemia	CNTROB →	+0.770	+0.144	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CSNK2A1 →	+0.669	+0.095	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902850 vs TUBG1 — SOFT_TISSUE

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