Positive regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, TOP2A, and IQGAP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G1/S phase transition activity versus TIMELESS in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMELESS →	+0.465	+0.103	.001	.005	3	7
BRCA	TOP2A →	+0.844	+0.084	<.001	.002	3	6
BRCA	IQGAP3 →	+0.963	+0.145	<.001	<.001	3	6
BRCA	ASF1B →	+0.784	+0.111	<.001	.003	3	6
BRCA	TICRR →	+0.550	+0.099	<.001	<.001	3	6
BRCA	KIFC1 →	+0.976	+0.145	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902808 vs TIMELESS — BRCA

Explore this scatter interactively →