Regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Regulation of cell cycle G1/S phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACNA2D1, WDR24, and EPS8L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle G1/S phase transition activity versus CACNA2D1 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CACNA2D1 →	+0.761	+0.045	<.001	<.001	3	7
BRCA	WDR24 →	-0.244	-0.022	.001	.006	3	7
HNSC	EPS8L2 →	-0.607	-0.055	<.001	<.001	3	7
OV	SULF1 →	+1.093	+0.041	<.001	<.001	3	6
OV	TUBB6 →	+0.399	+0.035	.001	<.001	3	6
UCEC	COG2 →	-0.227	-0.052	.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902806 vs CACNA2D1 — OV

Explore this scatter interactively →