Regulation of cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX5, LUC7L2, and PARP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle G1/S phase transition activity versus CBX5 in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBX5 →	+0.818	+0.133	.009	.004	3	7
SOFT_TISSUE	LUC7L2 →	+0.556	+0.221	.004	.005	2	7
SOFT_TISSUE	PARP1 →	+1.562	+0.233	.007	.009	2	6
BLOOD_Leukemia	DDOST →	-0.567	-0.122	.001	<.001	3	5
BLOOD_Leukemia	SRRT →	+0.532	+0.122	<.001	<.001	3	5
SOFT_TISSUE	FAM189B →	+0.793	+0.237	.003	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902806 vs CBX5 — BLOOD_Leukemia

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