Late endosome to lysosome transport

Across TCGA patient cohorts, RNA activity of the Late endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC1LI2, GOLGB1, and ATXN1L, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to lysosome transport activity versus DYNC1LI2 in THYM (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	DYNC1LI2 →	+1.711	+0.055	<.001	<.001	3	30
UVM	GOLGB1 →	+1.084	+0.045	<.001	<.001	3	30
THYM	ATXN1L →	+1.144	+0.042	<.001	<.001	3	30
THYM	SLC24A1 →	+1.075	+0.058	<.001	<.001	3	30
UVM	SPG11 →	+0.926	+0.035	<.001	<.001	3	29
THYM	GCC2 →	+1.105	+0.053	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902774 vs DYNC1LI2 — THYM

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