Late endosome to lysosome transport

Across TCGA cell cohorts, RNA activity of the Late endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL47, KLHL30, and KREMEN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL47 grouped by Late endosome to lysosome transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MRPL47 →	-0.413	-0.285	.004	.003	3	4
OESOPHAGUS	KLHL30 →	+0.507	+0.328	.009	.004	3	4
LUNG_NSCLC_LUSC	KREMEN1 →	-2.304	-0.312	.007	.006	3	4
LIVER	SENP5 →	-0.830	-0.458	.001	.001	3	3
BLOOD_Leukemia	ZNF718 →	-1.434	-0.296	.002	<.001	3	3
LIVER	UNC13D →	+2.833	+0.410	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL47 by Late endosome to lysosome transport activity — URINARY_TRACT

Explore this box plot interactively →