Positive regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G2/M phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SMC2, and SMC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G2/M phase transition activity versus RRM2 in LUAD (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRM2 →	+0.758	+0.062	<.001	<.001	3	9
UCEC	SMC2 →	+0.662	+0.086	<.001	<.001	3	9
LUAD	SMC4 →	+0.536	+0.068	<.001	<.001	3	9
BRCA	TFDP1_S23 →	+0.656	+0.030	<.001	<.001	3	9
LSCC	TK1 →	+0.738	+0.061	<.001	.002	3	9
HNSC	BAZ1B_S349 →	+0.963	+0.102	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902751 vs RRM2 — LUAD

Explore this scatter interactively →