Positive regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G2/M phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIN3A_S860, WDR43_S77, and DNMT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G2/M phase transition activity versus SIN3A_S860 in HNSC (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIN3A_S860 →	+0.810	+0.351	<.001	<.001	2	8
BRCA	WDR43_S77 →	+0.728	+0.230	<.001	<.001	3	7
LSCC	DNMT1 →	+0.404	+0.250	<.001	<.001	3	7
GBM	MAD2L1 →	+0.477	+0.232	<.001	.001	3	7
GBM	CPSF1 →	+0.220	+0.307	.003	<.001	3	7
BRCA	RBM17 →	+0.245	+0.244	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902751 vs SIN3A_S860 — HNSC

Explore this scatter interactively →