Negative regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGM2, PRR14L, and GRXCR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle G2/M phase transition activity versus TGM2 in LUNG_NSCLC_LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TGM2 →	+2.617	+0.703	<.001	.007	3	4
LARGE_INTESTINE	PRR14L →	-0.714	-0.544	<.001	.003	3	3
LARGE_INTESTINE	GRXCR2 →	-0.029	-0.740	.001	.001	3	3
STOMACH	CEP126 →	+1.824	+1.152	.004	.001	3	3
BREAST	JUN →	+0.984	+0.366	.008	.005	3	3
BLOOD_Leukemia	KLHL12 →	-0.428	-0.446	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902750 vs TGM2 — LUNG_NSCLC_LUAD

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