Negative regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR1, FTL, and CBWD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBR1 grouped by Negative regulation of lens fiber cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TGFBR1 →	-1.685	-1.752	.002	<.001	3	5
CNS	FTL →	+1.474	+0.978	.001	.004	3	4
BREAST	CBWD1 →	-0.914	-0.863	<.001	.002	3	4
BREAST	ZFP41 →	-1.059	-0.925	.003	.001	3	4
STOMACH	STRIP2 →	-1.259	-0.999	<.001	.004	3	4
SKIN	E2F1 →	-0.762	-1.103	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBR1 by Negative regulation of lens fiber cell differentiation activity — BONE

Explore this box plot interactively →