Negative regulation of lamellipodium organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANK1, PDSS1P1, and RNU7-119P, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lamellipodium organization activity versus KANK1 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KANK1 →	+0.934	+0.652	<.001	<.001	3	7
UCEC	PDSS1P1 →	+0.721	+0.693	.003	.001	3	4
UCEC	RNU7-119P →	+1.794	+0.819	<.001	<.001	3	3
LSCC	RNU6-1327P →	+1.137	+0.542	.003	.002	3	3
GBM	EIF1P1 →	+0.657	+0.416	.001	<.001	3	3
GBM	TCF3P1 →	+0.278	+0.382	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902744 vs KANK1 — LSCC

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