Regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID2, CRACD, and RIOK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARID2 grouped by Regulation of lamellipodium organization-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARID2 →	-0.769	-0.366	.004	.001	3	5
OVARY	CRACD →	-1.062	-0.374	.001	.001	2	5
OVARY	RIOK1 →	-0.652	-0.392	.003	<.001	3	4
OVARY	KRI1 →	-0.795	-0.439	.005	.009	3	4
OVARY	ACTR3B →	-1.143	-0.468	<.001	.004	3	4
OVARY	ELFN2 →	+1.590	+0.328	.003	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARID2 by Regulation of lamellipodium organization activity — BLOOD_Lymphoma

Explore this box plot interactively →