Apoptotic process involved in development

Across TCGA cell cohorts, RNA activity of the Apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZPR1, ARG1, and PYCARD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic process involved in development activity versus ZPR1 in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZPR1 →	+0.748	+0.874	.004	.007	3	5
BLOOD_Myeloma	ARG1 →	-0.159	-1.646	.001	<.001	3	3
OESOPHAGUS	PYCARD →	-3.010	-0.925	<.001	.004	3	3
LUNG_NSCLC_LUSC	ITPK1 →	-1.260	-1.484	.004	<.001	2	4
LUNG_NSCLC_LUSC	RAB11A →	-0.966	-1.567	<.001	.001	3	3
SKIN	DAG1 →	-0.925	-0.974	.005	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902742 vs ZPR1 — OESOPHAGUS

Explore this scatter interactively →