Negative regulation of chondrocyte proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of chondrocyte proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALLD, C8G, and COL5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chondrocyte proliferation activity versus PALLD in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PALLD →	+0.603	+0.095	<.001	.001	3	7
BRCA	C8G →	+0.432	+0.075	.001	.001	3	7
BRCA	COL5A1 →	+0.746	+0.085	<.001	<.001	3	7
CCRCC	COL5A2 →	+0.669	+0.091	<.001	.001	3	7
UCEC	ACTN1 →	+0.500	+0.076	<.001	.002	3	6
BRCA	VCL_S795 →	+0.603	+0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902731 vs PALLD — CCRCC

Explore this scatter interactively →