Negative regulation of chondrocyte proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of chondrocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTAGE3P, PRSS21, and ACTA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chondrocyte proliferation activity versus CTAGE3P in UCEC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTAGE3P →	+0.603	+0.796	.004	.002	3	3
BRCA	PRSS21 →	-1.463	-0.247	<.001	<.001	3	3
CCRCC	ACTA2 →	+0.893	+0.250	<.001	.001	3	3
CCRCC	PDE1A →	+0.790	+0.287	<.001	<.001	3	3
CCRCC	ECRG4 →	+1.213	+0.320	<.001	.003	3	3
CCRCC	CRISPLD1 →	+0.775	+0.198	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902731 vs CTAGE3P — UCEC

Explore this scatter interactively →