Negative regulation of chondrocyte proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chondrocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC183, MSRB3, and LDB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC183 grouped by Negative regulation of chondrocyte proliferation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCDC183 →	-1.144	-2.000	.002	<.001	3	4
SOFT_TISSUE	MSRB3 →	-1.606	-1.730	.001	<.001	3	4
SOFT_TISSUE	LDB1 →	-0.771	-1.423	.005	.002	3	4
CNS	NEU1 →	+0.946	+0.952	.002	.002	3	4
STOMACH	GDE1 →	+1.134	+1.188	.001	.004	3	4
URINARY_TRACT	APOBEC3D →	-1.425	-1.465	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC183 by Negative regulation of chondrocyte proliferation activity — BLOOD_Myeloma

Explore this box plot interactively →