Negative regulation of chondrocyte proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chondrocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRG6, MAPK8IP3, and PLCZ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADGRG6 grouped by Negative regulation of chondrocyte proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ADGRG6 →	+0.139	+1.103	.001	.008	2	5
UPPER_AERODIGESTIVE_TRACT	MAPK8IP3 →	-0.441	-1.559	.001	<.001	3	4
BLOOD_Lymphoma	PLCZ1 →	-0.279	-1.690	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DMTN →	-0.165	-1.144	.007	.001	3	3
LUNG_NSCLC_LUAD	LOX →	-0.100	-0.723	.005	.009	2	4
BLOOD_Myeloma	SPATA21 →	+0.362	+0.173	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADGRG6 by Negative regulation of chondrocyte proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →