Negative regulation of chondrocyte proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chondrocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD7, BMPR2, and GADD45B, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chondrocyte proliferation activity versus SMAD7 in LARGE_INTESTINE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMAD7 →	+2.015	+1.393	<.001	<.001	3	16
BLOOD_Leukemia	BMPR2 →	+1.527	+1.114	<.001	<.001	3	15
SOFT_TISSUE	GADD45B →	+0.977	+0.368	.009	.007	3	7
SOFT_TISSUE	OPTN →	+1.784	+0.573	<.001	.005	2	7
PANCREAS	BMP2K →	+0.766	+0.888	<.001	.001	3	6
BLOOD_Leukemia	PTPRJ →	+1.239	+0.673	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902731 vs SMAD7 — LARGE_INTESTINE

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