Positive regulation of proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of proteoglycan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKRD44, RGS10, and RIPOR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteoglycan biosynthetic process activity versus ANKRD44 in LSCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKRD44 →	-0.259	-0.046	<.001	<.001	3	6
HNSC	RGS10 →	-0.303	-0.096	.002	.001	3	5
HNSC	RIPOR2 →	-0.530	-0.103	.001	.001	3	5
LSCC	CD74 →	-0.525	-0.069	.001	.001	3	5
PDAC	PLCD3 →	+0.406	+0.068	<.001	<.001	3	5
HNSC	CTPS2 →	+0.361	+0.103	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902730 vs ANKRD44 — LSCC

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