Positive regulation of proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteoglycan biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNNB1, SLC2A10, and TCF7L2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNNB1 grouped by Positive regulation of proteoglycan biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTNNB1 →	-1.615	-0.461	<.001	<.001	3	12
BLOOD_Leukemia	SLC2A10 →	-0.312	-1.184	.007	.007	2	7
SKIN	TCF7L2 →	-0.221	-0.718	<.001	.006	2	6
LARGE_INTESTINE	SRRD →	+0.111	+0.269	.003	.009	3	4
BONE	LRRC8B →	-0.276	-1.720	.001	.001	3	4
LUNG_SCLC	AUP1 →	+0.221	+1.341	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNNB1 by Positive regulation of proteoglycan biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →