Positive regulation of proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLYWCH2, TMEM45A, and SNORC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FLYWCH2 grouped by Positive regulation of proteoglycan biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FLYWCH2 →	-0.698	-1.195	.002	.001	3	4
STOMACH	TMEM45A →	-2.878	-1.736	<.001	<.001	3	4
STOMACH	SNORC →	+1.338	+1.454	.009	.004	3	4
BREAST	TNNT1 →	-1.934	-0.797	.001	.004	3	4
BLOOD_Leukemia	RPS4Y1 →	-7.020	-1.207	<.001	<.001	3	4
BLOOD_Leukemia	KDM5D →	-4.137	-1.295	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FLYWCH2 by Positive regulation of proteoglycan biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →