Positive regulation of proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteoglycan biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK7, RANGAP1, and SLC2A4RG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCSK7 grouped by Positive regulation of proteoglycan biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PCSK7 →	-0.266	-0.142	.005	.003	3	5
LARGE_INTESTINE	RANGAP1 →	-0.168	-0.087	.001	.002	3	4
LUNG_SCLC	SLC2A4RG →	-0.283	-0.208	<.001	.001	3	4
BLOOD_Leukemia	ZNF708 →	+0.221	+0.167	.002	.005	3	4
LARGE_INTESTINE	TIGAR →	+0.159	+0.115	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	ARHGAP42 →	-0.281	-0.123	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCSK7 by Positive regulation of proteoglycan biosynthetic process activity — LIVER

Explore this box plot interactively →