Regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCD3, NOTCH1, and PKD1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuroblast proliferation activity versus SMARCD3 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMARCD3 →	+1.787	+0.100	<.001	<.001	3	12
BLOOD_Leukemia	NOTCH1 →	+1.774	+0.126	<.001	<.001	3	10
LARGE_INTESTINE	PKD1 →	+1.021	+0.046	<.001	.009	3	9
KIDNEY	TAF1C →	+0.981	+0.127	.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	ZNF335 →	+0.644	+0.114	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ZNF783 →	+1.140	+0.107	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902692 vs SMARCD3 — LARGE_INTESTINE

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