Positive regulation of neutrophil migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR63, PNRC2, and MPND, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR63 grouped by Positive regulation of neutrophil migration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR63 →	-0.500	-0.937	.005	<.001	3	4
SOFT_TISSUE	PNRC2 →	-0.777	-1.520	.007	<.001	3	4
SOFT_TISSUE	MPND →	-0.697	-0.975	.001	.005	3	4
LIVER	PSMD10 →	+1.001	+1.439	.001	.003	3	3
LIVER	CISD1 →	+0.771	+1.680	.001	<.001	3	3
SOFT_TISSUE	COMMD3 →	+1.352	+1.260	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR63 by Positive regulation of neutrophil migration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →