Regulation of neutrophil migration

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99, PITPNA, and ETFB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil migration activity versus CD99 in STOMACH (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CD99 →	+1.795	+0.348	.004	.004	2	7
BLOOD_Leukemia	PITPNA →	+0.914	+0.280	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ETFB →	+1.168	+0.307	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CFAP54 →	+0.969	+0.295	.009	.002	3	4
BLOOD_Lymphoma	WASHC3 →	+0.560	+0.208	<.001	.001	3	4
LUNG_SCLC	RARRES2 →	-1.005	-0.198	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902622 vs CD99 — STOMACH

Explore this scatter interactively →