Negative regulation of cellular response to vascular endothelial growth factor stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to vascular endothelial growth factor stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, SERPINF1, and P3H3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to vascular endothelial growth factor stimulus activity versus CYGB in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYGB →	+0.746	+0.099	.001	<.001	3	10
OV	SERPINF1 →	+0.896	+0.085	<.001	<.001	3	9
GBM	P3H3 →	+0.570	+0.064	<.001	<.001	3	9
BRCA	PCOLCE →	+0.640	+0.045	<.001	<.001	3	9
UCEC	SPARC →	+0.577	+0.104	<.001	<.001	3	8
UCEC	TAGLN →	+0.988	+0.105	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902548 vs CYGB — OV

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