Regulation of cellular response to vascular endothelial growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to vascular endothelial growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, NOP58, and LAMP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to vascular endothelial growth factor stimulus activity versus ITGB1 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGB1 →	+1.276	+0.097	<.001	.001	3	10
BLOOD_Lymphoma	NOP58 →	-0.829	-0.138	.002	<.001	3	10
LUNG_SCLC	LAMP1 →	+0.901	+0.118	.004	.001	3	9
STOMACH	GSN →	+2.250	+0.152	.009	<.001	3	8
OESOPHAGUS	CALR →	+1.191	+0.128	.004	<.001	3	8
PANCREAS	APP →	+1.028	+0.130	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902547 vs ITGB1 — BREAST

Explore this scatter interactively →