Regulation of protein autoubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein autoubiquitination pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are A-83-01, Lenalidomide, and Vismodegib, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, A-83-01 grouped by Regulation of protein autoubiquitination-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	A-83-01 →	-0.290	-1.991	.036	.022	3	2
BONE	Lenalidomide →	+0.205	+1.476	.040	.015	3	2
BONE	Vismodegib →	+0.516	+1.192	.021	.027	3	2
CNS	Sepantronium bromide →	-1.169	-0.392	.038	.006	2	2
SKIN	Dasatinib →	+0.955	+1.323	.029	.005	3	1
SKIN	BMS-536924 →	+0.647	+1.175	.036	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A-83-01 by Regulation of protein autoubiquitination activity — LUNG_SCLC

Explore this box plot interactively →