Regulation of protein localization to synapse

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM130, TTK, and BUB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to synapse activity versus TMEM130 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM130 →	+1.116	+0.599	<.001	<.001	3	5
UCEC	TTK →	-0.933	-0.725	<.001	<.001	3	5
UCEC	BUB1 →	-1.008	-0.707	<.001	.001	3	5
UCEC	NCAPH →	-0.832	-0.830	<.001	.001	3	4
UCEC	MELK →	-1.110	-0.783	.001	.002	3	4
UCEC	TRAIP →	-0.796	-0.664	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902473 vs TMEM130 — GBM

Explore this scatter interactively →