Regulation of protein localization to synapse

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXC8, PHLDB2, and CARMIL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to synapse activity versus HOXC8 in OVARY (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HOXC8 →	-1.758	-1.065	.007	.005	3	5
LARGE_INTESTINE	PHLDB2 →	+2.806	+1.064	.002	.002	3	4
BLOOD_Leukemia	CARMIL2 →	+2.375	+0.574	.001	.005	3	4
BLOOD_Leukemia	B3GNT2 →	+1.175	+0.871	<.001	.001	3	4
SOFT_TISSUE	MYB →	-0.805	-1.435	.002	<.001	3	4
BONE	UQCRC2 →	-0.608	-1.655	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902473 vs HOXC8 — OVARY

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