Positive regulation of mesenchymal stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mesenchymal stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC7B, TEAD1, and MYLK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC7B grouped by Positive regulation of mesenchymal stem cell proliferation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TTC7B →	+2.361	+1.231	.002	.001	3	6
LIVER	TEAD1 →	+1.288	+1.701	<.001	<.001	3	5
LIVER	MYLK →	+2.049	+1.701	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ILDR1 →	-1.509	-1.181	.001	.001	3	5
KIDNEY	TNPO1 →	+0.844	+1.273	.002	.002	3	5
KIDNEY	CUL2 →	+0.652	+1.144	.005	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC7B by Positive regulation of mesenchymal stem cell proliferation activity — STOMACH

Explore this box plot interactively →