Negative regulation of stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANP32E, CCDC150, and LAMTOR5-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell population maintenance activity versus ANP32E in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANP32E →	+0.648	+0.234	.001	.001	3	5
UCEC	CCDC150 →	+0.728	+0.236	.005	<.001	3	5
LSCC	LAMTOR5-AS1 →	+0.484	+0.322	.003	<.001	3	5
BRCA	PDCD11 →	+0.392	+0.272	.001	<.001	3	5
BRCA	DDX12P →	+0.743	+0.208	<.001	<.001	3	5
BRCA	SNHG20 →	+0.448	+0.246	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902455 vs ANP32E — LSCC

Explore this scatter interactively →