Negative regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX2, KDM2B, and NPHP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell population maintenance activity versus CBX2 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBX2 →	+1.377	+0.481	<.001	.001	3	6
BLOOD_Lymphoma	KDM2B →	+1.207	+0.889	.001	.001	3	6
BONE	NPHP4 →	+0.965	+1.800	.006	<.001	3	6
BLOOD_Leukemia	SCNN1D →	+0.902	+0.615	.005	.005	3	6
BONE	EIF4EBP2 →	+1.128	+2.072	.009	<.001	3	5
SOFT_TISSUE	PANK1 →	+1.117	+1.702	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902455 vs CBX2 — BLOOD_Leukemia

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