Negative regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTL6A, ENY2, and HNRNPK, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell population maintenance activity versus ACTL6A in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACTL6A →	+1.080	+1.662	.001	<.001	3	15
BONE	ENY2 →	+0.996	+1.627	<.001	<.001	3	14
LARGE_INTESTINE	HNRNPK →	+0.770	+1.663	<.001	<.001	3	14
LUNG_NSCLC_LUSC	HCFC1 →	+0.726	+1.659	.005	<.001	3	14
BONE	RBBP4 →	+1.509	+1.711	<.001	<.001	3	14
BONE	HMGB1 →	+1.666	+1.600	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902455 vs ACTL6A — LUNG_NSCLC_LUSC

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