Regulation of attachment of mitotic spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Regulation of attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS8L1, AURKB, and KIF20B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPS8L1 grouped by Regulation of attachment of mitotic spindle microtubules to kinetochore-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EPS8L1 →	+4.396	+0.157	<.001	<.001	3	7
STOMACH	AURKB →	-1.375	-0.201	.004	.001	2	7
PANCREAS	KIF20B →	-0.933	-0.206	.001	.001	3	5
URINARY_TRACT	ACER2 →	+2.059	+0.157	.002	<.001	3	5
LARGE_INTESTINE	PIMREG →	-1.225	-0.180	.004	<.001	3	5
SOFT_TISSUE	WRAP53 →	-0.531	-0.226	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPS8L1 by Regulation of attachment of mitotic spindle microtubules to kinetochore activity — URINARY_TRACT

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