Regulation of mitotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, PTTG3P, and RBMS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic cytokinesis activity versus WNK1 in LUAD (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WNK1 →	+0.372	+0.781	.002	<.001	3	5
BRCA	PTTG3P →	+1.228	+0.641	<.001	<.001	3	5
BRCA	RBMS3 →	-0.822	-0.791	<.001	<.001	3	4
GBM	FAT4 →	-0.830	-0.752	.001	<.001	3	4
CCRCC	KCNJ8 →	-1.070	-1.173	<.001	<.001	3	4
BRCA	SUV39H2 →	+0.622	+0.623	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902412 vs WNK1 — LUAD

Explore this scatter interactively →