Regulation of mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4G, SHROOM1, and ERAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA4G grouped by Regulation of mitotic cytokinesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEMA4G →	+1.947	+0.160	.009	.003	3	6
CNS	SHROOM1 →	+1.110	+0.104	<.001	.004	3	5
SOFT_TISSUE	ERAP2 →	-2.390	-0.330	.001	.001	3	5
BONE	RNH1 →	-0.712	-0.305	<.001	.002	3	5
SKIN	H2AC19 →	+1.601	+0.097	<.001	.007	3	5
PANCREAS	PSMD9 →	-0.502	-0.161	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA4G by Regulation of mitotic cytokinesis activity — STOMACH

Explore this box plot interactively →