Ceramide 1-phosphate transport

Across TCGA patient cohorts, RNA activity of the Ceramide 1-phosphate transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTRN, ATXN2L, and GARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide 1-phosphate transport activity versus UTRN in UCEC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UTRN →	-0.240	-0.054	.003	.001	3	6
UCEC	ATXN2L →	+0.201	+0.071	<.001	<.001	3	5
BRCA	GARS1 →	+0.332	+0.045	.002	<.001	3	5
LSCC	MDM1_S601 →	-0.577	-0.050	<.001	.001	3	5
HNSC	SMC3 →	-0.235	-0.042	.001	.005	3	5
HNSC	EIF4G1 →	+0.245	+0.054	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902389 vs UTRN — UCEC

Explore this scatter interactively →