Ceramide 1-phosphate transport

Across TCGA patient cohorts, RNA activity of the Ceramide 1-phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COMMD2, ARMCX5, and TCEAL4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide 1-phosphate transport activity versus COMMD2 in OV (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COMMD2 →	-0.493	-0.125	.002	<.001	3	3
OV	ARMCX5 →	-0.414	-0.121	.004	<.001	3	3
OV	TCEAL4 →	-0.424	-0.083	.002	.004	3	3
OV	NUP35 →	-0.382	-0.081	<.001	<.001	3	3
OV	LRRC40 →	-0.337	-0.070	.006	.008	3	3
LSCC	SYCN →	+0.186	+0.126	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902389 vs COMMD2 — OV

Explore this scatter interactively →